Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

VR Silva, LS Santos, RB Dias… - Cancer …, 2021 - Wiley Online Library
Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Dietary isothiocyanates inhibit cancer progression by modulation of epigenome

MK Sundaram, R Preetha, S Haque, N Akhter… - Seminars in Cancer …, 2022 - Elsevier
Cell cycle, growth, survival and metabolism are tightly regulated together and failure in
cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT …

Targeting cancer stem cells by nutraceuticals for cancer therapy

M Chu, C Zheng, C Chen, G Song, X Hu… - Seminars in cancer …, 2022 - Elsevier
Accumulating evidence has demonstrated that cancer stem cells (CSCs) play an essential
role in tumor progression and reoccurrence and drug resistance. Multiple signaling …

Phenolic compounds from Mediterranean foods as nutraceutical tools for the prevention of cancer: The effect of honey polyphenols on colorectal cancer stem-like cells …

D Cianciosi, TY Forbes-Hernández, J Ansary, E Gil… - Food chemistry, 2020 - Elsevier
Chemoresistance and development of relapses are ascribable to a rare cell population of
tumour mass: cancer stem cells (CSCs). Targeting CSCs could increase patients' survival …

Cruciferous vegetables, isothiocyanates, and prevention of bladder cancer

OL Veeranki, A Bhattacharya, L Tang… - Current pharmacology …, 2015 - Springer
Approximately 80% of human bladder cancers (BC) are non-muscle invasive when first
diagnosed and are usually treated by transurethral tumor resection. But 50–80% of patients …

[HTML][HTML] Redox regulation of stem-like cells though the CD44v-xCT axis in colorectal cancer: mechanisms and therapeutic implications

HQ Ju, YX Lu, DL Chen, T Tian, HY Mo, XL Wei… - Theranostics, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a common neoplastic disease and a frequent cause of death.
Drug resistance is a major challenge to CRC treatment and stem-like side-population (SP) …

Colorectal cancer stem cells and targeted agents

H Zhao, R Han, Z Wang, J Xian, X Bai - Pharmaceutics, 2023 - mdpi.com
Since their discovery, cancer stem cells have become a hot topic in cancer therapy research.
These cells possess stem cell-like self-renewal and differentiation capacities and are …

Targeting cervical cancer stem cells by phytochemicals

T Tripathi, J Yadav, D Janjua… - Current Medicinal …, 2024 - benthamdirect.com
Cervical cancer (CaCx) poses a significant global health challenge, ranking as the fourth
most common cancer among women worldwide. Despite the emergence of advanced …

Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study

LP Pereira, P Silva, M Duarte, L Rodrigues… - Nutrients, 2017 - mdpi.com
Colorectal cancer (CRC) recurrence is often attributable to circulating tumor cells and/or
cancer stem cells (CSCs) that resist to conventional therapies and foster tumor progression …

Targeted gene delivery therapies for cervical cancer

Á Áyen, Y Jimenez Martinez, H Boulaiz - Cancers, 2020 - mdpi.com
Despite being largely preventable through early vaccination and screening strategies,
cervical cancer is the most common type of gynecological malignancy worldwide and …