The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

Wnt signaling regulates a broad variety of processes during embryonic development and
disease. A hallmark of the Wnt signaling pathway is the formation of concentration gradients …

The concept of positional information proposes that cells acquire positional values as in a
coordinate system, which they interpret by developing in particular ways to give rise to …

A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the
dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in …

During mouse embryogenesis, diffusible growth factors, ie fibroblast growth factors, Wnt,
bone morphogenetic protein and Hedgehog family members, emanating from localized …

The concept of positional information is central to our understanding of how cells determine
their location in a multicellular structure and thereby their developmental fates …

During vertebrate embryonic development, the spinal cord is formed by the neural
derivatives of a neuromesodermal population that is specified at early stages of …

The aim of this study was to highlight the roles of perlecan in the regulation of the
development of the rudiment developmental cartilages and growth plate cartilages, and also …

The positional information theory proposes that a coordinate system provides information to
embryonic cells about their position and orientation along a patterning axis. Cells interpret …

Gradients of signaling proteins are essential for inducing tissue morphogenesis. However,
mechanisms of gradient formation remain controversial. Here we characterized the …