Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease

JC de la Torre - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Considerable information is currently available from neuroimaging, pathological, and
population-based prospective studies showing that vascular risk factors are independently …

[HTML][HTML] Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future

F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study

S Yasar, J Xia, W Yao, CD Furberg, QL Xue… - Neurology, 2013 - AAN Enterprises
Objectives: The aim of this study was to determine whether use of diuretics, angiotensin-1
receptor blockers (ARB), angiotensin-converting enzyme inhibitors (ACE-I), calcium channel …

Blood-brain barrier crossing renin-angiotensin drugs and cognition in the elderly: a meta-analysis

JK Ho, F Moriarty, JJ Manly, EB Larson, DA Evans… - …, 2021 - Am Heart Assoc
Hypertension is an established risk factor for cognitive decline and dementia in older adults,
highlighting the potential importance of antihypertensive treatments in prevention efforts …

[HTML][HTML] The coming of age of the angiotensin hypothesis in Alzheimer's disease: progress toward disease prevention and treatment?

PG Kehoe - Journal of Alzheimer's Disease, 2018 - content.iospress.com
There is wide recognition of a complex association between midlife hypertension and
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …

[HTML][HTML] 'Hearts and minds': association, causation and implication of cognitive impairment in heart failure

JA Cannon, JJV McMurray, TJ Quinn - Alzheimer's research & therapy, 2015 - Springer
The clinical syndrome of heart failure is one of the leading causes of hospitalisation and
mortality in older adults. An association between cognitive impairment and heart failure is …

Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia

Y Gao, R O'Caoimh, L Healy, DM Kerins, J Eustace… - BMJ open, 2013 - bmjopen.bmj.com
Objectives There is growing evidence that antihypertensive agents, particularly centrally
acting ACE inhibitors (CACE-Is), which cross the blood–brain barrier, are associated with a …

The association of renin-angiotensin system blockade use with the risks of cognitive impairment of aging and Alzheimer's disease: A meta-analysis

S Zhuang, HF Wang, X Wang, J Li, CM Xing - Journal of Clinical …, 2016 - Elsevier
A quantitative meta-analysis was performed to evaluate the association of renin-angiotensin
system blockade (RASB) use with the incidence of cognitive impairment of aging and …

Vascular risk factors and cognition in Parkinson's disease

A Pilotto, R Turrone, I Liepelt-Scarfone… - Journal of …, 2016 - content.iospress.com
Vascular risk factors have been associated with cognitive deficits and incident dementia in
the general population, but their role on cognitive dysfunction in Parkinson's disease (PD) is …

[HTML][HTML] Angiotensin converting enzyme inhibitors ameliorate brain inflammation associated with microglial activation: possible implications for Alzheimer's disease

N Torika, K Asraf, E Roasso, A Danon… - Journal of Neuroimmune …, 2016 - Springer
Angiotensin converting enzyme (ACE) converts Angiotensin I to a potent vasoconstrictor
angiotensin II (ANG II). ACE inhibitors (ACEIs) are widely used for the management of …