The neurobiology of activational aspects of motivation: exertion of effort, effort-based decision making, and the role of dopamine

JD Salamone, M Correa - Annual Review of Psychology, 2024 - annualreviews.org
Motivational processes are complex and multifaceted, with both directional and activational
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …

Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology

JD Salamone, SE Yohn, L López-Cruz, N San Miguel… - Brain, 2016 - academic.oup.com
Motivation has been defined as the process that allows organisms to regulate their internal
and external environment, and control the probability, proximity and availability of stimuli. As …

Dopamine, effort-based choice, and behavioral economics: basic and translational research

JD Salamone, M Correa, JH Yang, R Rotolo… - Frontiers in behavioral …, 2018 - frontiersin.org
Operant behavior is not only regulated by factors related to the quality or quantity of
reinforcement, but also by the work requirements inherent in performing instrumental …

Quantifying motivation with effort-based decision-making paradigms in health and disease

TTJ Chong, V Bonnelle, M Husain - Progress in brain research, 2016 - Elsevier
Motivation can be characterized as a series of cost–benefit valuations, in which we weigh
the amount of effort we are willing to expend (the cost of an action) in return for particular …

Neural substrates underlying effort, time, and risk-based decision making in motivated behavior

MR Bailey, EH Simpson, PD Balsam - Neurobiology of Learning and …, 2016 - Elsevier
All mobile organisms rely on adaptive motivated behavior to overcome the challenges of
living in an environment in which essential resources may be limited. A variety of influences …

The psychopharmacology of effort-related decision making: dopamine, adenosine, and insights into the neurochemistry of motivation

JD Salamone, M Correa, S Ferrigno, JH Yang… - Pharmacological …, 2018 - ASPET
Effort-based decision making is studied using tasks that offer choices between high-effort
options leading to more highly valued reinforcers versus low-effort/low-reward options …

The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences

JD Salamone, M Correa, S Yohn, LL Cruz… - Behavioural …, 2016 - Elsevier
This review paper is focused upon the involvement of mesolimbic dopamine (DA) and
related brain systems in effort-based processes. Interference with DA transmission affects …

Altered nucleus accumbens functional connectivity precedes apathy in Parkinson's disease

LA Morris, SJ Harrison, TR Melzer, JC Dalrymple-Alford… - Brain, 2023 - academic.oup.com
Work in animal and human neuroscience has identified neural regions forming a network
involved in the production of motivated, goal-directed behaviour. In particular, the nucleus …

Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to …

C Carratalá-Ros, A Martínez-Verdú… - …, 2023 - Springer
Background Depression is a disorder twice as common in women than in men. There are
sex differences in the symptomatology and treatment response to this disorder. Impairments …

Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: exertion of effort vs. anhedonia

JD Salamone, A Ecevitoglu, C Carratala-Ros… - Brain Research …, 2022 - Elsevier
Instrumental behavior is a very complex and multifaceted process. Behavioral output during
instrumental performance is influenced by a variety of factors, including associative …