Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …

DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to
specific sequences to induce or repress gene expression. Comparative genomics has …

Abstract ABSCISIC ACID–RESPONSIVE ELEMENT BINDING PROTEIN1 (AREB1)(ie,
ABF2) is a basic domain/leucine zipper transcription factor that binds to the abscisic acid …

Abstract Systems analysis of metabolic and growth functions in microbial organisms is
rapidly developing and maturing. Such studies are enabled by reconstruction, at the …

An extracellular matrix composed of a layered meshwork of β-glucans, chitin, and
mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae. This organelle …

Identifying the functional elements encoded in a genome is one of the principal challenges
in modern biology. Comparative genomics should offer a powerful, general approach. Here …

T-bet and GATA3 regulate the CD4+ T cell Th1/Th2 cell fate decision but little is known
about the interplay between these factors outside of the murine Ifng and Il4/Il5/Il13 loci. Here …

Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit
many of the responses that are evoked in cells by changes in certain environmental …

Yeast cells possess a remarkable capacity to adhere to abiotic surfaces, cells and tissues.
These adhesion properties are of medical and industrial relevance. Pathogenic yeasts such …