Unraveling Emerging Anal Cancer Clinical Biomarkers from Current Immuno-Oncogenomics Advances

S Iseas, G Mariano, L Gros, N Baba-Hamed… - Molecular Diagnosis & …, 2024 - Springer
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with
high-risk human papillomavirus (HPV) and is currently one of the fastest-growing causes of …

Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates

JJ Barchi Jr - Frontiers in Immunology, 2022 - frontiersin.org
For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate
Antigens, TACAs) have been the target of both passive and active anticancer …

[HTML][HTML] Compressed phenotypic screens for complex multicellular models and high-content assays

BE Mead, C Kummerlowe, N Liu, WE Kattan, T Cheng… - bioRxiv, 2023 - ncbi.nlm.nih.gov
High-throughput phenotypic screens leveraging biochemical perturbations, high-content
readouts, and complex multicellular models could advance therapeutic discovery yet remain …

Gastric Cancer Biomarker Candidates Identified by Machine Learning and Integrative Bioinformatics: Toward Personalized Medicine

VSP Sinnarasan, D Paul, R Das… - OMICS: A Journal of …, 2023 - liebertpub.com
Gastric cancer (GC) is among the leading causes of cancer-related deaths worldwide. The
discovery of robust diagnostic biomarkers for GC remains a challenge. This study sought to …

[HTML][HTML] Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

H Kimura, K Lahouel, C Tomasetti, NJ Roberts - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Interpretation of variants identified during genetic testing is a significant clinical challenge. In
this study, we developed a high-throughput CDKN2A functional assay and characterized all …