The demonstration in the 1960s that cis-diamminedichloroplatinum (II), or cisplatin, inhibits
cellular division of Escherichia coli 1 led to the subsequent discovery that this simple …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

Platinum compounds represent one of the great success stories of metals in medicine.
Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a …

For the purpose of this review, active targeting in cancer research encompasses strategies
wherein a ligand for a cell surface receptor expressed on tumor cells is used to deliver a …

The conjugation of biologically active molecules is a powerful tool for drug discovery used to
target a variety of multifunctional diseases including cancer. Conjugated drugs can provide …

The novel steroidal conjugate 17-α-[2-phenylpyridyl-4-ethynyl]-19-nortestosterone (LEV-
ppy)(1) and the steroid–C, N-chelate ruthenium (II) conjugate [Ru (η6-p-cymene)(LEV-ppy) …

This focused review is devoted to our advances in developing trans platinum complexes as
antitumoral complexes, in particular those bearing aliphatic amines. It includes some …

The deleterious effects of metal-catalyzed reactive oxygen species (ROS) in biological
systems can be seen in a wide variety of pathological conditions including cancer …

A range of androgen conjugates with non-conventional platinum (II) complexes have been
synthesised with the aim of targeting tumour cells since many display elevated levels of the …

An iridium (III) pentamethylcyclopentadienyl catalyst supported by 6, 6′-dihydroxy-2, 2′-
bipyridine displays exquisite selectivity in acceptorless alcohol dehydrogenation of cyclic α …