CD8+ T cells are critical for elimination of cancer cells. Factors within the tumor
microenvironment (TME) can drive these cells to a hypofunctional state known as …

Immunotherapy has revolutionized the treatment of cancer. In particular, immune checkpoint
blockade, bispecific antibodies, and adoptive T-cell transfer have yielded unprecedented …

The development of chimeric antigen receptor T cells (CAR-T cells) has marked a new era in
cancer immunotherapy. Based on a multitude of durable complete remissions in patients …

Background The survival of patients with cervical cancer who are treated with cisplatin in
conjunction with the topoisomerase I inhibitor topotecan is enhanced when compared with …

Immune checkpoint inhibitors (ICIs) use antibodies that block cell surface immune
checkpoint proteins with great efficacy in treating immunogenic or “immune hot” tumors such …

Background Drug-free in vitro activation (IVA) is a new protocol to activate residual dormant
follicles for fertility restoration in patients with premature ovarian insufficiency (POI) …

Background Single-cell RNA sequencing enables studying cells individually, yet high gene
dimensions and low cell numbers challenge analysis. And only a subset of the genes …