Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
PDA Vignali, K DePeaux, MLJ Watson, C Ye… - Nature …, 2023 - nature.com
CD8+ T cells are critical for elimination of cancer cells. Factors within the tumor
microenvironment (TME) can drive these cells to a hypofunctional state known as …
microenvironment (TME) can drive these cells to a hypofunctional state known as …
[HTML][HTML] Apoptosis: A Janus bifrons in T-cell immunotherapy
Immunotherapy has revolutionized the treatment of cancer. In particular, immune checkpoint
blockade, bispecific antibodies, and adoptive T-cell transfer have yielded unprecedented …
blockade, bispecific antibodies, and adoptive T-cell transfer have yielded unprecedented …
[HTML][HTML] CARs and drugs: pharmacological ways of boosting CAR-T-cell therapy
DC Harrer, J Dörrie, N Schaft - International Journal of Molecular …, 2023 - mdpi.com
The development of chimeric antigen receptor T cells (CAR-T cells) has marked a new era in
cancer immunotherapy. Based on a multitude of durable complete remissions in patients …
cancer immunotherapy. Based on a multitude of durable complete remissions in patients …
[HTML][HTML] Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication
TC van der Sluis, FJ van Haften… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background The survival of patients with cervical cancer who are treated with cisplatin in
conjunction with the topoisomerase I inhibitor topotecan is enhanced when compared with …
conjunction with the topoisomerase I inhibitor topotecan is enhanced when compared with …
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy
Immune checkpoint inhibitors (ICIs) use antibodies that block cell surface immune
checkpoint proteins with great efficacy in treating immunogenic or “immune hot” tumors such …
checkpoint proteins with great efficacy in treating immunogenic or “immune hot” tumors such …
[HTML][HTML] Drug-free in vitro activation combined with ADSCs-derived exosomes restores ovarian function of rats with premature ovarian insufficiency
Q Li, Z Zhang, W Shi, Z Li, Y Xiao, J Zhang… - Journal of Ovarian …, 2024 - Springer
Background Drug-free in vitro activation (IVA) is a new protocol to activate residual dormant
follicles for fertility restoration in patients with premature ovarian insufficiency (POI) …
follicles for fertility restoration in patients with premature ovarian insufficiency (POI) …
[HTML][HTML] COMSE: analysis of single-cell RNA-seq data using community detection-based feature selection
Background Single-cell RNA sequencing enables studying cells individually, yet high gene
dimensions and low cell numbers challenge analysis. And only a subset of the genes …
dimensions and low cell numbers challenge analysis. And only a subset of the genes …