Although the gastrointestinal (GI) tract possesses intrinsic neural plexuses that allow a
significant degree of autonomy over GI functions, the central nervous system (CNS) provides …

The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent
vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory …

Summary Glucagon-like peptide-1 (GLP-1)-based therapies control glycemia in type 2
diabetic (T2D) patients. However, in some patients the treatment must be discontinued …

Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disease with a
significant impact on patients' quality of life and a high socioeconomic burden. And the …

Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder. It is widely
believed that IBS is caused by a deficient intake of dietary fiber, and most physicians …

Diet plays an important role not only in the pathophysiology of irritable bowel syndrome
(IBS), but also as a tool that improves symptoms and quality of life. The effects of diet seem …

The nod-like receptor protein-3 (NLRP3)-mediated pyroptosis is involved in kidney
diseases. Thioredoxin interacting protein (TXNIP) directly interacts with NLRP3. This study …

There has been an exponential rise in diabetes mellitus (DM) cases on a global scale.
Diabetes affects almost every system of the body, and the nervous system is no exception …

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, the pathophysiology of
which is not completely known, although it has been shown that genetic/social learning …

Highlights•Vagal afferents to the gut are activated by CCK, leptin, 5HT, GLP-1 and PYY 3–
36.•The actions of CCK on vagal afferents are potentiated by leptin.•In diet induced obesity …