Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations

L Dresser, R Wlodarski, K Rezania… - Journal of clinical medicine, 2021 - mdpi.com
Myasthenia gravis (MG) is an autoimmune neurological disorder characterized by defective
transmission at the neuromuscular junction. The incidence of the disease is 4.1 to 30 cases …

Myasthenia gravis: subgroup classification and therapeutic strategies

NE Gilhus, JJ Verschuuren - The Lancet Neurology, 2015 - thelancet.com
Myasthenia gravis is an autoimmune disease that is characterised by muscle weakness and
fatigue, is B-cell mediated, and is associated with antibodies directed against the …

Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society

N Melzer, T Ruck, P Fuhr, R Gold, R Hohlfeld… - Journal of …, 2016 - Springer
Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular
synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and …

The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes

A Marx, F Pfister, B Schalke, G Saruhan-Direskeneli… - Autoimmunity …, 2013 - Elsevier
The thymus plays distinct roles in the pathogenesis of the different Myasthenia gravis (MG)
subtypes. Inflammatory, neoplastic and age-related alterations of the thymus are of pivotal …

Epidemiology, diagnostics, and biomarkers of autoimmune neuromuscular junction disorders

AR Punga, P Maddison, JM Heckmann… - The Lancet …, 2022 - thelancet.com
Autoimmune neuromuscular junction disorders are rare. However, myasthenia gravis is
being increasingly recognised in people older than 50 years. In the past 5–10 years …

Thymus and autoimmunity

A Marx, Y Yamada, K Simon-Keller, B Schalke… - Seminars in …, 2021 - Springer
The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

Autoimmune disorders of the nervous system: pathophysiology, clinical features, and therapy

S Bhagavati - Frontiers in neurology, 2021 - frontiersin.org
Remarkable discoveries over the last two decades have elucidated the autoimmune basis of
several, previously poorly understood, neurological disorders. Autoimmune disorders of the …

Exploring the gut microbiome in myasthenia gravis

AYK Thye, JWF Law, LTH Tan, S Thurairajasingam… - Nutrients, 2022 - mdpi.com
The human gut microbiota is vital for maintaining human health in terms of immune system
homeostasis. Perturbations in the composition and function of microbiota have been …

Myasthenia gravis and infectious disease

NE Gilhus, F Romi, Y Hong, GO Skeie - Journal of neurology, 2018 - Springer
Background and purpose Myasthenia gravis (MG) is an autoimmune disease with muscular
weakness as the only symptom, and often with immunosuppressive treatment. All these …

Associations between HLA and autoimmune neurological diseases with autoantibodies

S Muñiz-Castrillo, A Vogrig, J Honnorat - Autoimmunity Highlights, 2020 - Springer
Recently, several autoimmune neurological diseases have been defined by the presence of
autoantibodies against different antigens of the nervous system. These autoantibodies have …