With the markedly increased diagnosis and incidence of cancer in the population, tumor
bone metastasis has become a frequent event in tumor patients. Healthy bone integrity is …

A harmonious balance between osteoblast and osteoclast activity guarantees optimal bone
formation and resorption, pathological conditions affecting the bone may arise. In recent …

Fracture nonunion remains a great challenge for orthopedic surgeons. Fracture repair
comprises of three phases, the inflammatory, repair and remodeling stage. Extensive …

Fracture combined with traumatic brain injury (TBI) is one of the most common and serious
types of compound trauma in the clinic and is characterized by dysfunction of cellular …

Bone loss is prevalent in clinical pathological phenomena such as osteoporosis, which is
characterized by decreased osteoblast function and number, increased osteoclast activity …

Background Approximately 10% of all bone fractures result in delayed fracture healing or
non‐union; thus, the identification of biomarkers and prognostic factors is of great clinical …

Ferroptosis is an iron‐dependent form of programmed cell death and an important type of
biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can …

In this study, we investigated the mechanistic role and prognostic significance of the long
coding RNA (lncRNA) KCNQ1OT1 in colorectal cancer (CRC). KCNQ1OT1 levels were …

Background Cisplatin-based cytotoxic chemotherapy is considered to be the first-line
therapy for advanced bladder cancer (BC), but resistance to cisplatin limits its antitumor …

Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …