AGC kinases, mechanisms of regulation and innovative drug development
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
The choreography of protein kinase PDK1 and its diverse substrate dance partners
The protein kinase PDK1 phosphorylates at least 24 distinct substrates, all of which belong
to the AGC protein kinase group. Some substrates, such as conventional PKCs, undergo …
to the AGC protein kinase group. Some substrates, such as conventional PKCs, undergo …
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
M Sacerdoti, LZF Gross, AM Riley, K Zehnder… - Science …, 2023 - science.org
The activation of at least 23 different mammalian kinases requires the phosphorylation of
their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide …
their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide …
Drugs currently under investigation for the treatment of invasive candidiasis
MW McCarthy, TJ Walsh - Expert opinion on investigational drugs, 2017 - Taylor & Francis
Introduction: The widespread implementation of immunosuppressants, immunomodulators,
hematopoietic stem cell transplantation and solid organ transplantation in clinical practice …
hematopoietic stem cell transplantation and solid organ transplantation in clinical practice …
An insight into the role of protein kinases as virulent factors, regulating pathogenic attributes in Candida albicans
Candida albicans is a polymorphic, opportunistic pathogen, member of normal human
microbiome causing candidiasis. It causes wide range of infections from superficial skin …
microbiome causing candidiasis. It causes wide range of infections from superficial skin …
Identification of key phospholipids that bind and activate atypical PKCs
PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of
regulation by calcium and the neutral lipid diacylglycerol. To better understand the …
regulation by calcium and the neutral lipid diacylglycerol. To better understand the …
Therapeutic effects of different polar fractions of hawthorn extract on blood stasis model rats revealed by liquid chromatography–mass spectrometry metabolomics
L Luo, Q Xue, Y Qi, L Zeng… - Journal of Separation …, 2021 - Wiley Online Library
Hawthorn, a commonly used traditional Chinese medicine, has been suggested to have
therapeutic effects on cardiovascular disease. However, effective fractions of hawthorn …
therapeutic effects on cardiovascular disease. However, effective fractions of hawthorn …
The fungal MCC/eisosome complex: an unfolding story
K Kolláth-Leiß, F Kempken - Physiology and Genetics: Selected Basic and …, 2018 - Springer
The plasma membrane subdomain MCC, together with the cytoplasmic protein complex
eisosome, is an important key regulator in plasma membrane organisation, and, in this …
eisosome, is an important key regulator in plasma membrane organisation, and, in this …
An Epidemiological Correlation of Oral Candidiasis Mice Model Study of an Isolate from Mollugo pentaphylla Linn. and In silico Docking Approach
P Niyogi, S Pattnaik, L Maharana, R Mohapatra… - Iranian Journal of …, 2019 - Springer
The aim of the present study was to isolate the active compound against Candida albicans
from the methanolic extract of aerial part of Mollugo pentaphylla Linn. and to peruse in vivo …
from the methanolic extract of aerial part of Mollugo pentaphylla Linn. and to peruse in vivo …
Changes in domain organization of the plasma membrane in the stress response
K Vaškovičová - 2020 - dspace.cuni.cz
MCC/eisosomes are yeast plasma membrane microdomains that respond to changes in
both extracellular and intracellular conditions and activate important stress-related signaling …
both extracellular and intracellular conditions and activate important stress-related signaling …