The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …

Cells and tissues can sense and react to the modifications of the physico-chemical
properties of the extracellular environment (ECM) through integrin-based adhesion sites and …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

▪ Abstract The superfamily of intermediate filament (IF) proteins contains at least 65 distinct
proteins in man, which all assemble into∼ 10 nm wide filaments and are principal structural …

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …

Nuclear pore complexes have recently been shown to play roles in gene activation; however
their potential involvement in metazoan transcription remains unclear. Here we show that …

Mechanical properties of the nuclear envelope have implications for cell and nuclear
architecture as well as gene regulation. Using isolated Xenopus oocyte nuclei, we have …

Background Nuclear genome size varies 300 000-fold, whereas transcriptome size varies
merely 17-fold. In the largest genomes nearly all DNA is non-genic secondary DNA, mostly …

Intermediate filaments are cytoskeletal polymers encoded by a large family of differentially
expressed genes that provide crucial structural support in the cytoplasm and nucleus of …