Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors
Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …
immune system but is also key to inflammatory disease. Chemokines are central to this …
The Role of Oxidative Stress in Intervertebral Disc Degeneration: Mechanisms and Therapeutic Implications
X Chen, A Zhang, K Zhao, H Gao, P Shi, Y Chen… - Ageing Research …, 2024 - Elsevier
Oxidative stress is one of the main driving mechanisms of intervertebral disc degeneration
(IDD). Oxidative stress has been associated with inflammation in the intervertebral disc …
(IDD). Oxidative stress has been associated with inflammation in the intervertebral disc …
Deciphering the role of glycosaminoglycans in GPCR signaling
S Savransky, AD White, JP Vilardaga - Cellular Signalling, 2024 - Elsevier
G protein-coupled receptors (GPCR) and glycosaminoglycans (GAGs) are two essential
components of the cell surface that regulate physiological processes in the body. GPCRs …
components of the cell surface that regulate physiological processes in the body. GPCRs …
Chemokine Oligomers and the Impact of Fondaparinux Binding
GP Szekeres, DP Dyer, RL Miller… - Journal of the American …, 2024 - ACS Publications
Heparin, a widely used clinical anticoagulant, is generally well-tolerated; however,
approximately 1% of patients develop heparin-induced thrombocytopenia (HIT), a serious …
approximately 1% of patients develop heparin-induced thrombocytopenia (HIT), a serious …
Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling
A Millet, N Jendzjowsky - Frontiers in Immunology, 2023 - frontiersin.org
Sensory neurons cooperate with barrier tissues and resident immune cells to form a
significant aspect of defensive strategies in concert with the immune system. This assembly …
significant aspect of defensive strategies in concert with the immune system. This assembly …
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during inflammation
MJ Priestley, AK Hains, IZ Mulholland, S Spijkers-Shaw… - bioRxiv, 2024 - biorxiv.org
The glycocalyx is a proteoglycan-rich layer present on the surface of all mammalian cells
that is particularly prevalent on endothelial cells lining the vasculature. It has been …
that is particularly prevalent on endothelial cells lining the vasculature. It has been …
Heparan sulphate binding controls in vivo half-life of the HpARI protein family
F Colomb, A Jamwal, A Ogunkanbi, T Frangova… - bioRxiv, 2024 - biorxiv.org
The parasitic nematode Heligmosomoides polygyrus bakeri secretes the HpARI family,
which bind to IL-33, either suppressing (HpARI1 and HpARI2) or enhancing (HpARI3) …
which bind to IL-33, either suppressing (HpARI1 and HpARI2) or enhancing (HpARI3) …