Overview of the Antimicrobial Compounds Produced by Members of the Bacillus subtilis Group

S Caulier, C Nannan, A Gillis, F Licciardi… - Frontiers in …, 2019 - frontiersin.org
Over the last seven decades, applications using members of the Bacillus subtilis group have
emerged in both food processes and crop protection industries. Their ability to form survival …

Actinomycetes: still a source of novel antibiotics

O Genilloud - Natural product reports, 2017 - pubs.rsc.org
Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

Antibiotics and bacterial resistance in the 21st century

RJ Fair, Y Tor - Perspectives in medicinal chemistry, 2014 - journals.sagepub.com
Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters

P Cimermancic, MH Medema, J Claesen, K Kurita… - Cell, 2014 - cell.com
Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …

Antibiotics and the gut microbiota

SR Modi, JJ Collins, DA Relman - The Journal of clinical …, 2014 - Am Soc Clin Investig
Antibiotics have been a cornerstone of innovation in the fields of public health, agriculture,
and medicine. However, recent studies have shed new light on the collateral damage they …

Fungal–fungal co-culture: a primer for generating chemical diversity

SL Knowles, HA Raja, CD Roberts… - Natural Product …, 2022 - pubs.rsc.org
Covering: 2002 to 2020 In their natural environment, fungi must compete for resources. It
has been hypothesized that this competition likely induces the biosynthesis of secondary …

Antibiotics for emerging pathogens

MA Fischbach, CT Walsh - Science, 2009 - science.org
Antibiotic-resistant strains of pathogenic bacteria are increasingly prevalent in hospitals and
the community. New antibiotics are needed to combat these bacterial pathogens, but …

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

K Yamanaka, KA Reynolds… - Proceedings of the …, 2014 - National Acad Sciences
Recent developments in next-generation sequencing technologies have brought recognition
of microbial genomes as a rich resource for novel natural product discovery. However …

Prospects for new antibiotics: a molecule-centered perspective

CT Walsh, TA Wencewicz - The Journal of antibiotics, 2014 - nature.com
There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

Marine natural products: a new wave of drugs?

R Montaser, H Luesch - Future medicinal chemistry, 2011 - Taylor & Francis
The largely unexplored marine world that presumably harbors the most biodiversity may be
the vastest resource to discover novel 'validated'structures with novel modes of action that …