Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Positron emission tomography with selective radioligands advances the drug discovery and
development process by revealing information about target engagement, proof of …

Hyperphosphorylated tau aggregates, also known as neurofibrillary tangles, are a hallmark
neuropathological feature of Alzheimer's disease (AD). Molecular imaging of tau by positron …

Tau is one of several proteins associated with frontotemporal dementia. While knowing
which protein is causing a patient's disease is crucial, no biomarker currently exists for …

[18F] MK-6240 is a second-generation tau PET-tracer to quantify neurofibrillary tangles in-
vivo. However, individually variable levels of meningeal uptake induce spill-in-effects into …

In vivo characterization of pathologic deposition of tau protein in the human brain by PET
imaging is a promising tool in drug development trials of Alzheimer disease (AD). 6-(fluoro …

Introduction Alzheimer's disease (AD) is one of the most common causes of dementia.
Pathogenic variants in the presenilin 1 (PSEN1) gene are the most frequent cause of early …

The inadequate information about the in vivo pathological, physiological, and neurological
impairments, as well as the absence of in vivo tools for assessing brain penetrance and the …

Background: Isoquinoline analogs are an important, structurally diverse class of compounds
that are extensively used as pharmaceuticals. Derivatives containing the isoquinoline …

Objective A new tau PET tracer [18F] MK-6240 has been developed; however, its dosimetry
and pharmacokinetics have been published only for a European population. This study …