The skin is the outermost layer of the body with an extensive surface area of approximately
1· 8 m2, and is the first line of defence against a multitude of external pathogens and …

Significance: Although most researches into the changes in skin with age focus on the
unwelcome aesthetic aspects of the aging skin, skin deterioration with age is more than a …

As the proportion of the ageing population in industrialized countries continues to increase,
the dermatological concerns of the aged grow in medical importance. Intrinsic structural …

Mammalian skin comprises a multi-layered epithelium, the epidermis, and an underlying
connective tissue, the dermis. The epidermal extracellular matrix is a basement membrane …

Skin aging is associated with changes in cutaneous physiology including interactions with a
skin microbial community. A striking alteration and diversification in the skin microbiome with …

Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs)
communicate with organ systems to adjust immune response, provide signals for …

It is well known that advancing age is a factor that affects the normal course of wound
healing. The population over the age of 65 years is increasing globally, and this may be …

Age-related sensory impairment is a slow and gradual progress, which affects multiple
modalities. Two contradictory hypotheses exist about the age-related decline of sensory …

Despite an increase in life expectancy that indicates positive human development, a new
challenge is arising. Aging is positively associated with biological and cognitive …

Despite the growing interest by researchers into cellular senescence, a hallmark of cellular
aging, its role in human skin remains equivocal. The skin is the largest and most accessible …