Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
[HTML][HTML] Looping the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
[HTML][HTML] Cohesin and CTCF control the dynamics of chromosome folding
In mammals, interactions between sequences within topologically associating domains
enable control of gene expression across large genomic distances. Yet it is unknown how …
enable control of gene expression across large genomic distances. Yet it is unknown how …
Transcription shapes 3D chromatin organization by interacting with loop extrusion
EJ Banigan, W Tang… - Proceedings of the …, 2023 - National Acad Sciences
Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
[HTML][HTML] Direct observation of a condensate effect on super-enhancer controlled gene bursting
Enhancers are distal DNA elements believed to loop and contact promoters to control gene
expression. Recently, we found diffraction-sized transcriptional condensates at genes …
expression. Recently, we found diffraction-sized transcriptional condensates at genes …
G-quadruplexes associated with R-loops promote CTCF binding
P Wulfridge, Q Yan, N Rell, J Doherty, S Jacobson… - Molecular Cell, 2023 - cell.com
CTCF is a critical regulator of genome architecture and gene expression that binds
thousands of sites on chromatin. CTCF genomic localization is controlled by the recognition …
thousands of sites on chromatin. CTCF genomic localization is controlled by the recognition …
CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation
In most bacteria, chromosome segregation is driven by the ParAB S system where the
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …
Single-molecule visualization of twin-supercoiled domains generated during transcription
R Janissen, R Barth, M Polinder… - Nucleic acids …, 2024 - academic.oup.com
Transcription-coupled supercoiling of DNA is a key factor in chromosome compaction and
the regulation of genetic processes in all domains of life. It has become common knowledge …
the regulation of genetic processes in all domains of life. It has become common knowledge …
Structures of CTCF–DNA complexes including all 11 zinc fingers
The CCCTC-binding factor (CTCF) binds tens of thousands of enhancers and promoters on
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …