Cystic fibrosis: a mucosal immunodeficiency syndrome

TS Cohen, A Prince - Nature medicine, 2012 - nature.com
Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that
regulates the transport of ions and the movement of water across the epithelial barrier …

Vibrio vulnificus: An Environmental and Clinical Burden

SP Heng, V Letchumanan, CY Deng… - Frontiers in …, 2017 - frontiersin.org
Vibrio vulnificus is a Gram negative, rod shaped bacterium that belongs to the family
Vibrionaceae. It is a deadly, opportunistic human pathogen which is responsible for the …

Pseudomonas aeruginosa elastase (LasB) as a therapeutic target

MJ Everett, DT Davies - Drug Discovery Today, 2021 - Elsevier
The Pseudomonas aeruginosa LasB elastase (elastase B, pseudolysin) is the predominant
protease in the P. aeruginosa secretome. It has been shown to hydrolyse a vast array of host …

Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa

W Hwang, SS Yoon - Scientific reports, 2019 - nature.com
Pseudomonas aeruginosa displays intrinsic resistance to many antibiotics and known to
acquire actively genetic mutations for further resistance. In this study, we attempted to …

Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung

M Hogardt, J Heesemann - Between pathogenicity and commensalism, 2012 - Springer
Pseudomonas aeruginosa is the leading pathogen of chronic cystic fibrosis (CF) lung
infection. Life-long persistance of P. aeruginosa in the CF lung requires a sophisticated …

Anti-PqsR compounds as next-generation antibacterial agents against Pseudomonas aeruginosa: A review

V Soheili, AS Tajani, R Ghodsi, BSF Bazzaz - European journal of …, 2019 - Elsevier
Nowadays, due to spreading antibiotic resistance among clinically relevant pathogens, the
requirement of novel therapeutic approaches is felt more than ever. One of the alternative …

Anaerobiosis influences virulence properties of Pseudomonas aeruginosa cystic fibrosis isolates and the interaction with Staphylococcus aureus

R Pallett, LJ Leslie, PA Lambert, I Milic, A Devitt… - Scientific reports, 2019 - nature.com
The airways of individuals with cystic fibrosis (CF) are abundantly colonised by
Staphylococcus aureus and Pseudomonas aeruginosa. Co-infecting hypoxic regions of …

The role of Vibrio vulnificus virulence factors and regulators in its infection-induced sepsis

G Li, MY Wang - Folia microbiologica, 2020 - Springer
Due to the development of Marine aquaculture, infections caused by Vibrio vulnificus are
common all over the world. Symptoms of V. vulnificus infection vary from gastrointestinal …

1H NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol

T Chen, J Sheng, Y Fu, M Li, J Wang… - Journal of Proteome …, 2017 - ACS Publications
Quorum sensing (QS) is a process of bacterial communication that has been a novel target
for drug discovery. Pyocyanin quantification assay confirmed that resveratrol was an …

Protective role of gut commensal microbes against intestinal infections

MY Yoon, K Lee, SS Yoon - Journal of Microbiology, 2014 - Springer
The human gastrointestinal tract is colonized by multitudes of microorganisms that exert
beneficial effects on human health. Mounting evidence suggests that intestinal microbiota …