SAMHD1 in cancer: curse or cure?

K Schott, C Majer, A Bulashevska, L Childs… - Journal of Molecular …, 2022 - Springer
Human sterile α motif and HD domain-containing protein 1 (SAMHD1), originally described
as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) …

Identification of prognostic genes in the tumor microenvironment of hepatocellular carcinoma

S Xiang, J Li, J Shen, Y Zhao, X Wu, M Li… - Frontiers in …, 2021 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors
in the world. The efficacy of immunotherapy usually depends on the interaction of …

Interrogating epigenome toward personalized approach in cutaneous melanoma

EG Dobre, C Constantin, M Costache… - Journal of Personalized …, 2021 - mdpi.com
Epigenetic alterations have emerged as essential contributors in the pathogenesis of
various human diseases, including cutaneous melanoma (CM). Unlike genetic changes …

SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway

Z Chen, Z Jiang, L Meng, Y Wang, M Lin, Z Wei… - Cell Cycle, 2022 - Taylor & Francis
ABSTRACT SAMHD1 was reported to be related with the development of tumors, while its
function in gastric cancer (GC) has not been elucidated yet. Here, we investigated the role …

Revisiting miRNA association with melanoma recurrence and metastasis from a machine learning point of view

A Korfiati, K Grafanaki, GC Kyriakopoulos… - International journal of …, 2022 - mdpi.com
The diagnostic and prognostic value of miRNAs in cutaneous melanoma (CM) has been
broadly studied and supported by advanced bioinformatics tools. From early studies using …

Molecular Classifiers in Skin Cancers: Challenges and Promises

A Azimi, P Fernandez-Peñas - Cancers, 2023 - mdpi.com
Simple Summary Skin cancers are common and sometimes difficult to diagnose
malignancies that occur worldwide. Most skin cancers are diagnosed by visual assessment …

Deciphering the role of wound healing genes in skin cutaneous melanoma: Insights into expression, methylation, mutations, and therapeutic implications

Y Zhang, C Gao, J Luo, A Khan… - International Wound …, 2024 - Wiley Online Library
Abstract Skin Cutaneous Melanoma (SKCM) is a form of cancer that originates in the
pigment‐producing cells, known as melanocytes, of the skin. Delay wound healing is often …

Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs

Z Chen, J Hu, S Ying, A Xu - Oncology Letters, 2021 - spandidos-publications.com
Human sterile alpha motif and HD‑domain‑containing protein 1 (SAMHD1) has been
identified as a GTP or dGTP‑dependent deoxynucleotide triphosphohydrolase (dNTPase) …

Multiomics Integration at Single-Cell Resolution Using Bayesian Networks: A Case Study in Hepatocellular Carcinoma

M Jihad, İ Yet - Omics: a journal of integrative biology, 2023 - liebertpub.com
Multiomics data integration is one of the leading frontiers of complex disease research and
integrative biology. The advances in single-cell sequencing technologies offer yet another …

Identification of Immune Function-Related Subtypes in Cutaneous Melanoma

L Liu, J Zhu, T Jin, M Huang, Y Chen, L Xu, W Chen… - Life, 2021 - mdpi.com
Tumour immunotherapy combined with molecular typing is a new therapy to help select
patients. However, molecular typing algorithms related to tumour immune function have not …