Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease

I Cortese, DS Reich, A Nath - Nature Reviews Neurology, 2021 - nature.com
Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused
by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic …

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

CS Tan, IJ Koralnik - The Lancet Neurology, 2010 - thelancet.com
Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal brain disease
caused by reactivation of the polyomavirus JC. Knowledge of the characteristics of PML has …

[HTML][HTML] Human polyomaviruses in disease and cancer

T Dalianis, HH Hirsch - Virology, 2013 - Elsevier
Today the human polyomavirus (HPyV) family consists of 10 members, BK virus (BKV) and
JC virus (JCV) isolated 40 years ago and the more recently identified KI virus (KIPyV), WU …

BK virus: opportunity makes a pathogen

HH Hirsch, DR Snydman - Clinical Infectious Diseases, 2005 - academic.oup.com
More than 70% of the general population worldwide has serological evidence of exposure to
Polyomavirus hominis type 1, better known as BK virus (BKV). BKV infection typically occurs …

The human JC polyomavirus (JCPyV): virological background and clinical implications

HH Hirsch, P Kardas, D Kranz, C Leboeuf - Apmis, 2013 - Wiley Online Library
JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …

JC virus infection of the brain

AK Bag, JK Curé, PR Chapman… - American Journal …, 2010 - Am Soc Neuroradiology
Since its initial description, there have been significant changes in the epidemiology,
pathogenesis, and clinical and imaging manifestations of JCV infection of brain. The most …

Progressive multifocal leukoencephalopathy: why gray and white matter

S Gheuens, C Wüthrich… - Annual Review of …, 2013 - annualreviews.org
Since it was first described in 1958, progressive multifocal leukoencephalopathy (PML), a
demyelinating disease of the brain caused by the polyomavirus JC (JCV), has evolved …

The spectrum of progressive multifocal leukoencephalopathy: a practical approach

T Bartsch, T Rempe, F Leypoldt… - European journal of …, 2019 - Wiley Online Library
John Cunningham virus (JCV) infection of the central nervous system causes progressive
multifocal leukoencephalopathy (PML) in patients with systemic immunosuppression. With …

Human polyomavirus reactivation: disease pathogenesis and treatment approaches

CF De Gascun, MJ Carr - Journal of Immunology Research, 2013 - Wiley Online Library
JC and BK polyomaviruses were discovered over 40 years ago and have become
increasingly prevalent causes of morbidity and mortality in a variety of distinct …

Comparison of PCR-southern hybridization and quantitative real-time PCR for the detection of JC and BK viral nucleotide sequences in urine and cerebrospinal fluid

C Ryschkewitsch, P Jensen, J Hou, G Fahle… - Journal of virological …, 2004 - Elsevier
The presence of the human polyomaviruses JCV and BKV in immunocompromised patients
can lead to lethal diseases and conditions including progressive multifocal …