Regulation of postabsorptive and postprandial glucose metabolism by insulin-dependent and insulin-independent mechanisms: an integrative approach

GD Dimitriadis, E Maratou, A Kountouri, M Board… - Nutrients, 2021 - mdpi.com
Glucose levels in blood must be constantly maintained within a tight physiological range to
sustain anabolism. Insulin regulates glucose homeostasis via its effects on glucose …

Regulation of adipocyte lipolysis

G Frühbeck, L Méndez-Giménez… - Nutrition research …, 2014 - cambridge.org
In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans

J Tong, RL Prigeon, HW Davis, M Bidlingmaier… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE The orexigenic gut hormone ghrelin and its receptor are present in pancreatic
islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in …

The molecular brakes of adipose tissue lipolysis

Y Li, Z Li, DA Ngandiri, M Llerins Perez, A Wolf… - Frontiers in …, 2022 - frontiersin.org
Adaptation to changes in energy availability is pivotal for the survival of animals. Adipose
tissue, the body's largest reservoir of energy and a major source of metabolic fuel, exerts a …

Gut-derived serotonin is a multifunctional determinant to fasting adaptation

G Sumara, O Sumara, JK Kim, G Karsenty - Cell metabolism, 2012 - cell.com
Energy release from cellular storage is mandatory for survival during fasting. This is
achieved through lipolysis and liver gluconeogenesis. We show here that in the mouse, gut …

Physiological effect of ghrelin on body systems

Y Akalu, MD Molla, G Dessie… - International journal of …, 2020 - Wiley Online Library
Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of
physiological effects. In this review, we found/confirmed that ghrelin has effect on all body …

The importance of caloric restriction in the early improvements in insulin sensitivity after Roux-en-Y gastric bypass surgery

JM Isbell, RA Tamboli, EN Hansen, J Saliba… - Diabetes …, 2010 - Am Diabetes Assoc
OBJECTIVE Many of the metabolic benefits of Roux-en-Y gastric bypass (RYGB) occur
before weight loss. In this study we investigated the influence of caloric restriction on the …

Ghrelin's relationship to blood glucose

BK Mani, K Shankar, JM Zigman - Endocrinology, 2019 - academic.oup.com
Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …

[HTML][HTML] Impact of different bariatric surgical procedures on insulin action and β-cell function in type 2 diabetes

E Ferrannini, G Mingrone - Diabetes care, 2009 - ncbi.nlm.nih.gov
The prevalence of obesity appears to have reached a plateau in the US between 2003 and
2007 (1), but the obesity epidemic is still rampant in many other countries—especially in the …

[HTML][HTML] Intestinal cholecystokinin controls glucose production through a neuronal network

GWC Cheung, A Kokorovic, CKL Lam, M Chari… - Cell metabolism, 2009 - cell.com
Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to
nutrients such as lipids to lower food intake. Here we report that a primary increase of CCK …