Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

BACKGROUND Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in
their function leading to decreased insulin secretion or may arise from insulin resistance and …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

The growing field of 'Developmental Origin of Health and Disease'(DOHaD) generally
reflects environmental influences from mother to child. The importance of maternal lifestyle …

The incorporation of mitochondria in the eukaryotic cell is one of the most enigmatic events
in the course of evolution. This important organelle was thought to be only the powerhouse …

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating
effects of young blood on aged tissues. However, the specific rejuvenating mechanisms …

Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with
systemic pathologies, including reproductive disorders in male diabetic patients. However …

Male fertility is declining in developed countries, as well as in developing countries. External
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …

We aimed to investigate mitochondrial function, biogenesis and autophagy in the brain of
type 2 diabetes (T2D) and Alzheimer's disease (AD) mice. Isolated brain mitochondria and …