Global burden of liver disease: 2023 update

H Devarbhavi, SK Asrani, JP Arab, YA Nartey… - Journal of …, 2023 - Elsevier
Liver disease accounts for two million deaths annually and is responsible for 4% of all
deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related …

Diagnosis and management of autoimmune hepatitis

L Muratori, AW Lohse, M Lenzi - bmj, 2023 - bmj.com
Autoimmune hepatitis is an inflammatory disease of the liver of unknown cause that may
progress to liver cirrhosis and end stage liver failure if diagnosis is overlooked and treatment …

A phase 3 trial of seladelpar in primary biliary cholangitis

GM Hirschfield, CL Bowlus, MJ Mayo… - … England Journal of …, 2024 - Mass Medical Soc
Background Effective treatments for patients with primary biliary cholangitis are limited.
Seladelpar, a peroxisome proliferator–activated receptor delta agonist, has potential …

Autoimmune hepatitis

BT Beretta-Piccoli, G Mieli-Vergani… - The Rose and Mackay …, 2024 - Elsevier
Autoimmune hepatitis (AIH) is an inflammatory liver disease, affecting mainly females,
characterized by elevated transaminase and immunoglobulin G (IgG) levels, interface …

[HTML][HTML] Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study

GM Hirschfield, ML Shiffman, A Gulamhusein… - Hepatology, 2023 - journals.lww.com
Seladelpar efficacy and safety at 3 months in patients with... : Hepatology Seladelpar
efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a …

[HTML][HTML] Helicobacter Pylori and Autoimmune Diseases: Involving Multiple Systems

L Wang, ZM Cao, LL Zhang, X Dai, Z Liu… - Frontiers in …, 2022 - frontiersin.org
The modern Gastroenterology have witnessed an essential stride since Helicobacter pylori
was first found in the stomach and then its pathogenic effect was discovered. According to …

[HTML][HTML] Primary biliary cholangitis: Epidemiology, prognosis, and treatment

J Trivella, BV John, C Levy - Hepatology communications, 2023 - journals.lww.com
Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease
characterized by a destructive, small duct, and lymphocytic cholangitis, and marked by the …

[HTML][HTML] Global incidence and prevalence of autoimmune hepatitis, 1970–2022: a systematic review and meta-analysis

JW Hahn, HR Yang, JS Moon, JY Chang, K Lee… - …, 2023 - thelancet.com
Background Autoimmune hepatitis (AIH) varies significantly in incidence and prevalence
across countries and regions. We aimed to examine global, regional, and national trends in …

[HTML][HTML] Greater transplant-free survival in patients receiving obeticholic acid for primary biliary cholangitis in a clinical trial setting compared to real-world external …

CFM Perez, H Fisher, S Hiu, D Kareithi, F Adekunle… - Gastroenterology, 2022 - Elsevier
Background & Aims The Primary Biliary Cholangitis (PBC) Obeticholic Acid (OCA)
International Study of Efficacy (POISE) randomized, double-blind, placebo-controlled trial …

[HTML][HTML] Epidemiology, natural history, and outcomes of primary sclerosing cholangitis: a systematic review of population-based studies

PJ Trivedi, CL Bowlus, KK Yimam, H Razavi… - Clinical Gastroenterology …, 2022 - Elsevier
Background & Aims The aim of this study was to quantify the global epidemiology of primary
sclerosing cholangitis (PSC), alongside the incidence of liver transplantation, cancer, and …