B cell epitope spreading: mechanisms and contribution to autoimmune diseases

C Cornaby, L Gibbons, V Mayhew, CS Sloan… - Immunology letters, 2015 - Elsevier
While a variety of factors act to trigger or initiate autoimmune diseases, the process of
epitope spreading is an important contributor in their development. Epitope spreading is a …

The complexity of Sjögren's syndrome: novel aspects on pathogenesis

R Jonsson, P Vogelsang, R Volchenkov, A Espinosa… - Immunology letters, 2011 - Elsevier
In Sjögren's syndrome, like in most other autoimmune diseases, the enigma leading to a
pathogenic attack against self has not yet been solved. By definition, the disease must be …

A comprehensive review of autoantibodies in primary Sjögren's syndrome: clinical phenotypes and regulatory mechanisms

NC Kyriakidis, EK Kapsogeorgou, AG Tzioufas - Journal of autoimmunity, 2014 - Elsevier
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by periepithelial
lymphocytic infiltrates in affected tissues and the production of plethora of autoantibodies …

Autoantibody profiling to follow evolution of lupus syndromes

NJ Olsen, QZ Li, J Quan, L Wang, A Mutwally… - Arthritis research & …, 2012 - Springer
Introduction Identification of patients who are in early stages of lupus is currently done
through clinical evaluation and is not greatly facilitated by available diagnostic tests …

Toll-like receptor 3 stimulation promotes Ro52/TRIM21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway

NC Kyriakidis, EK Kapsogeorgou… - Clinical & …, 2014 - academic.oup.com
Up-regulated expression of Ro52/tripartite motif-containing protein 21 (TRIM21),
Ro60/TROVE domain family, member 2 (TROVE2) and lupus LA protein/Sjögren's syndrome …

Autoantibodies in Sjögren's syndrome: clinical presentation and regulatory mechanisms

AG Tzioufas, IP Tatouli, HM Moutsopoulos - La Presse Médicale, 2012 - Elsevier
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease mostly affecting the
exocrine glands. A large number of autoantibodies have been detected in the serum of …

TLR7 activation of age-associated B cells mediates disease in a mouse model of primary Sjögren's disease

A Punnanitinont, EM Kasperek, C Zhu… - Journal of leukocyte …, 2024 - academic.oup.com
Primary Sjögren's disease (pSD)(also referred to as Sjögren's syndrome) is an autoimmune
disease that primarily occurs in women. In addition to exocrine gland dysfunction, pSD …

B-cell epitopes of the intracellular autoantigens Ro/SSA and La/SSB: tools to study the regulation of the autoimmune response

JG Routsias, AG Tzioufas - Journal of autoimmunity, 2010 - Elsevier
A common serologic finding in systemic autoimmune diseases is the presence of
autoantibodies against intracellular autoantigens. Although their pathogenesis is not fully …

CDetection. v2: One-pot assay for the detection of SARS-CoV-2

X Wang, Y Chen, X Cheng, SQ Wang, Y Hu… - Frontiers in …, 2023 - frontiersin.org
Introduction The ongoing 2019 coronavirus disease pandemic (COVID-19), caused by
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, is a global …

Systemic manifestations of primary Sjögren's syndrome in the NOD. B10Sn-H2b/J mouse model

J Kiripolsky, L Shen, Y Liang, A Li, L Suresh, Y Lian… - Clinical …, 2017 - Elsevier
Animal models that recapitulate human disease are crucial for the study of Sjögren's
Syndrome (SS). While several SS mouse models exist, there are few primary SS (pSS) …