From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …
misfolded protein accumulations may be found in the diverse signaling pathways of the …
Mechanisms of vascular aging
Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …
[HTML][HTML] mTOR as a central regulator of lifespan and aging
The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
[HTML][HTML] Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …
most common cause of human dementia. AD is characterized by accumulation of abnormal …
Impact of intermittent fasting on health and disease processes
Humans in modern societies typically consume food at least three times daily, while
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …
Effect of rapamycin on aging and age-related diseases—past and future
R Selvarani, S Mohammed, A Richardson - Geroscience, 2021 - Springer
In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …
life. This observation resulted in a sea-change in how researchers viewed aging. This was …
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial …
mechanism by which ageing promotes vascular pathologies is compromising endothelial …
Microglial mTOR activation upregulates Trem2 and enhances β-amyloid plaque clearance in the 5XFAD Alzheimer's disease model
The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key
cellular processes including metabolism and differentiation; however, the role of mTOR in …
cellular processes including metabolism and differentiation; however, the role of mTOR in …
Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice
Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB)
function, plays a major role in determining cognitive capability. Recent studies suggest that …
function, plays a major role in determining cognitive capability. Recent studies suggest that …