The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …

XBP1 is a key regulator of the unfolded protein response (UPR), which is involved in a wide
range of physiological and pathological processes. XBP1 ablation in liver causes profound …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

Serine hydrolases perform crucial roles in many biological processes, and several of these
enzymes are targets of approved drugs for indications such as type 2 diabetes, Alzheimer's …

In this review, novel aspects of the role of esterases, which contribute to the metabolism of
10% of therapeutic drugs, are described. Esterases hydrolyze the compounds that contain …

Background & Aims Binge drinking in patients with metabolic syndrome accelerates the
development of alcohol-associated liver disease. However, the underlying mechanisms …

Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis
reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes …

Phenotypic screening is making a comeback in drug discovery as the maturation of chemical
proteomics methods has facilitated target identification for bioactive small molecules. A …