Background: CD28, a cell surface glycoprotein receptor, predominantly expressed on
activated T cells, belongs to the Ig superfamily and provides a critical co-stimulatory signal …

Group 2 innate lymphoid cells (ILC2) are implicated in allergic asthma as an early innate
source of the type 2 cytokines IL-5 and IL-13. However, their induction in house dust mite …

Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2
immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be …

Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28
costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell …

Background Asthma is a common immune disease with high morbidity in children. Type 2
inflammation is the center of asthma development, and mainly mediated by a subset of …

The role of CD28‐mediated costimulation in secondary CD8+ T‐cell responses remains
controversial. Here, we have used two tools—blocking mouse anti‐mouse CD28‐specific …

The intracerebral infection of mice with Theiler's murine encephalomyelitis virus (TMEV)
represents a well-established animal model for multiple sclerosis (MS). Because CD28 is …

Rapid activation and proliferative expansion of specific CD8+ memory T (CD8+ TM) cells
upon antigen re‐encounter is a critical component of the adaptive immune response that …

IL-13 driven Th2 immunity is indispensable for host protection against infection with the
gastrointestinal nematode Nippostronglus brasiliensis. Disruption of CD28 mediated …

Allergic asthma is a chronic inflammatory lung disease mediated by type 2 cytokines
produced by T helper 2 (Th2) cells as well as the recently discovered group 2 innate …