Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage
growth. Throughout the years, the molecular defect underlying many of the diseases has …

Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

Background Oral clefts, that is, clefts of the lip and/or cleft palate (CL/P), are the most
common craniofacial birth defects with an approximate incidence of~ 1/700. To date …

To keep pace with the rapid advancements in molecular genetics and rare diseases
research, we have updated the list of ectodermal dysplasias based on the latest …

Backgrounds Cleft lip with or without cleft palate (CL/P) is the most common congenital
craniofacial anomaly, including non-syndromic cleft lip with or without cleft palate and cleft …

Objective Gout is characterised by severe interleukin (IL)-1-mediated joint inflammation
induced by monosodium urate crystals. Since IL-37 is a pivotal anti-inflammatory cytokine …

Like all developmental processes, odontogenesis is highly complex and dynamically
regulated, with hundreds of genes co‐expressed in reciprocal networks. Tooth agenesis …

Tooth agenesis and orofacial clefts represent the most common developmental anomalies
and their co-occurrence is often reported in patients as well in animal models. The aim of the …