[HTML][HTML] Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

[HTML][HTML] Mesenchymal stem cell-derived exosomes: applications in regenerative medicine

MD Hade, CN Suire, Z Suo - Cells, 2021 - mdpi.com
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …

[HTML][HTML] Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

D Zhu, Z Li, K Huang, TG Caranasos, JS Rossi… - Nature …, 2021 - nature.com
Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …

Therapeutic and diagnostic translation of extracellular vesicles in cardiovascular diseases: roadmap to the clinic

S Sahoo, M Adamiak, P Mathiyalagan, F Kenneweg… - Circulation, 2021 - Am Heart Assoc
Exosomes are small membrane-bound vesicles of endocytic origin that are actively
secreted. The potential of exosomes as effective communicators of biological signaling in …

Exosome-eluting stents for vascular healing after ischaemic injury

S Hu, Z Li, D Shen, D Zhu, K Huang, T Su… - Nature biomedical …, 2021 - nature.com
Drug-eluting stents implanted after ischaemic injury reduce the proliferation of endothelial
cells and vascular smooth muscle cells and thus neointimal hyperplasia. However, the …

Exosomes derived from kartogenin-preconditioned mesenchymal stem cells promote cartilage formation and collagen maturation for enthesis regeneration in a rat …

J Cai, J Xu, Z Ye, L Wang, T Zheng… - … American Journal of …, 2023 - journals.sagepub.com
Background: Poor tendon-to-bone healing in chronic rotator cuff tears (RCTs) is related to
unsatisfactory outcomes. Exosomes derived from mesenchymal stem cells reportedly …

A minimally invasive exosome spray repairs heart after myocardial infarction

J Yao, K Huang, D Zhu, T Chen, Y Jiang, J Zhang… - ACS …, 2021 - ACS Publications
Myocardial infarction (MI) remains the most common cause of death worldwide. Many MI
survivors will suffer from recurrent heart failure (HF), which has been recognized as a …

Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment

Z Wei, Z Chen, Y Zhao, F Fan, W Xiong, S Song, Y Yin… - Biomaterials, 2021 - Elsevier
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) with anti-apoptotic and
anti-inflammatory properties have been intensively studied. However, rapid clearance by the …

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

S Hu, Z Li, H Lutz, K Huang, T Su, J Cores… - Science …, 2020 - science.org
The progression in the hair follicle cycle from the telogen to the anagen phase is the key to
regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair …