The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single
genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce …

Molecular biology is currently a fast-advancing science. Sequencing techniques are getting
cheaper, but the interpretation of genetic variants requires expertise and computational …

One objective of human genetics is to unveil the variants that contribute to human diseases.
With the rapid development and wide use of next-generation sequencing (NGS), massive …

Simple Summary Subclinical mastitis represents a significant disease in dairy animals and
negatively impacts udder health. Genetics, pathogens, and poor health and management …

Background: Accurately determining variant pathogenicity is critical in the diagnosis of
cardiac channelopathies; however, it remains unknown how variant pathogenicity status …

Single-nucleotide polymorphisms (SNPs) are the most common genetic variations for
various complex human diseases, including cancers. Genome-wide association studies …

Identifying pathogenetic variants and inferring their impact on protein–protein interactions
sheds light on their functional consequences on diseases. Limited by the availability of …

Aims Chemotherapy‐induced peripheral neuropathy (PN) is a treatment limiting toxicity of
paclitaxel. We evaluated if EPHA genetic variation (EPHA4, EPHA5, EPHA6, and EPHA8) is …

Poly-ADP ribose polymerase (PARP) inhibitors are constantly increasing in their indications
for use as anti-cancer treatment in various neoplasms, the majority of which are linked with …

Haemoglobinopathies are the commonest monogenic diseases worldwide and are caused
by variants in the globin gene clusters. With over 2400 variants detected to date, their …