The myosin holoenzyme is a multimeric protein complex consisting of heavy chains and light
chains. Myosin light chains are calmodulin family members which are crucially involved in …

Myosin-X (Myo10) is an unconventional myosin with MyTH4-FERM domains that is best
known for its striking localization to the tips of filopodia and its ability to induce filopodia …

Aberrant actomyosin interactions contribute to a wide range of pathophysiological conditions
including heart failure, neurodegenerative disorders, and tumor growth. Despite surgical …

Myosin motors perform many fundamental functions in eukaryotic cells by providing force
generation, transport or tethering capacity. Motor activity control within the cell involves …

Unconventional myosins are a superfamily of actin‐based molecular motors playing diverse
roles including cellular trafficking, mechanical supports, force sensing and transmission, etc …

The transcription antiterminator RfaH has been shown to undergo major structural
rearrangements to perform multiple functions. Structural determination of the C-terminal …

The potentials of mean force (PMFs) along the end‐to‐end distance of two different helical
peptides have been obtained and benchmarked using the adaptive steered molecular …

We use machines to move, to lift, and to build. In a similar way, cells use machines to grow,
to reproduce, and to live. These machines play essential roles in cellular functions such as …

It is unclear whether the reverse-direction myosin (myosin VI) functions as a monomer or
dimer in cells and how it generates large movements on actin. We deleted a stable, single-α …

Background Non-small-cell lung cancer (NSCLC) is the most prevalent form of lung cancer.
Circular RNA (circRNA) has emerged as a key player in the development of NSCLC by …