Long-lasting changes of brain function in response to experience rely on diverse forms of
activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

Synaptic dysfunction is associated with many brain disorders, but robust human cell models
to study synaptic transmission and plasticity are lacking. Instead, current in vitro studies on …

De novo heterozygous mutations in STXBP1/Munc18-1 cause early infantile epileptic
encephalopathies (EIEE4, OMIM# 612164) characterized by infantile epilepsy …

The plethora of functions of glutamate in the brain are mediated by the complementary
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …

Research on endocannabinoid signaling has greatly advanced our understanding of how
the excitability of neural circuits is controlled in health and disease. In general …

Endocannabinoid (eCB) signaling is markedly decreased in the hippocampus (Hip) of aged
mice, and the genetic deletion of the cannabinoid receptor type 1 (CB1) leads to an early …

Abstract The endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG), a key modulator of
synaptic transmission in mammalian brain, is produced in dendritic spines and then crosses …

Endocannabinoids (ECBs) depress transmitter release at sites throughout the brain. Here,
we describe another form of ECB signaling that triggers a novel form of long-term …

L-Theanine is a characteristic amino acid in tea with various effects including antioxidant
and anti-inflammatory effects. Previously, most studies had reported that L-theanine …