CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all
contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in …

Monocyte/macrophages play an important role in orchestrating the immune response. The
present review refers to C/EBPβ, which is a key transcription factor regulating monocytic …

Delta-secretase cleaves both APP and Tau to mediate the formation of amyloid plaques and
neurofibrillary tangle in Alzheimer's disease (AD). However, how aging contributes to an …

Immunosuppressive cells have been highlighted in research due to their roles in tumor
progression and treatment failure. Myeloid-derived suppressor cells (MDSCs) are among …

CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding
protein family, and these proteins function as transcription factors in many biological …

Currently, breast cancer is the leading cause of cancer-related death in women. Therefore,
there is an urgent need to develop alternative therapeutic measures against this deadly …

ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ)
metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its …

ApoE4 is a major genetic risk determinant for Alzheimer's disease (AD) and drives its
pathogenesis via Aβ-dependent and-independent pathways. C/EBPβ, a proinflammatory …

Human immunodeficiency virus type 1 (HIV-1) has been shown to replicate productively in
cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent …

TLR stimulation triggers a signaling pathway via MyD88 and IL-1R-associated kinase 4 that
is essential for proinflammatory cytokine induction. Although NF-κB has been shown to be …