Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries.
The disease, caused by protozoan parasites of the Trypanosoma genus, is a major cause of …

Salivarian trypanosomes are single cell extracellular parasites that cause infections in a
wide range of hosts. Most pathogenic infections worldwide are caused by one of four major …

We report full-length draft de novo genome assemblies for 16 widely used inbred mouse
strains and find extensive strain-specific haplotype variation. We identify and characterize …

Summary Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of
chronic and end-stage kidney disease, which results in a significant global health disparity …

APOL1 harbors C–terminal sequence variants (G1 and G2), which account for much of the
increased risk for kidney disease in sub–Saharan African ancestry populations. Expression …

Trypanosoma brucei rhodesiense and T. brucei gambiense, the causative agents of Human
African Trypanosomiasis, are transmitted by tsetse flies. Within the vector, the parasite …

Black Americans are at increased risk for preeclampsia. Genetic variants in apolipoprotein
L1 (APOL1) account for much of the increased risk for kidney disease in blacks. APOL1 is …

Trypanosoma brucei, Leishmania spp., and T. cruzi are flagellate protozoans of the family
Trypanosomatidae and the causative agents of human African trypanosomiasis …

Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game
animals around the world. Through co-evolution with the mammalian immune system …

Epidemics of both forms of human African trypanosomiasis (HAT) are confined to spatially
stable foci in Sub-Saharan Africa while tsetse distribution is widespread. Infection rates of …