Context Menopause, the permanent cessation of menses, reflects oocyte depletion and loss
of gonadal steroids. It is preceded by a transition state, the perimenopause, which is …

Every woman who lives past midlife will experience menopause, which, by definition, is
complete cessation of ovarian function. This process might occur spontaneously (natural …

Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …

Women spend approximately one-third of their lives with menopause, which occurs around
50 years of age. It is now appreciated that several important metabolic and cardiovascular …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

Context The thermoregulatory center in the hypothalamus is stimulated by neurokinin 3
receptor (NK3R) activation and inhibited by estrogen-negative feedback. This balance is …

Objective: Menopausal vasomotor symptoms (VMS) may result from altered
thermoregulatory control in brain regions innervated by neurokinin 3 receptor-expressing …

Background Hot flushes affect 70% of menopausal women and often severely impact
physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is …

Evidence has been accumulating that, in men, some of the biological actions traditionally
attributed to testosterone acting via the androgen receptor may in fact be dependent on its …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …