Myosteatosis in the context of skeletal muscle function deficit: an interdisciplinary workshop at the National Institute on Aging
R Correa-de-Araujo, O Addison, I Miljkovic… - Frontiers in …, 2020 - frontiersin.org
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases
with aging and is recognized to negatively correlate with muscle mass, strength, and mobility …
with aging and is recognized to negatively correlate with muscle mass, strength, and mobility …
Understanding the bone in cancer metastasis
J Fornetti, AL Welm, SA Stewart - Journal of Bone and Mineral …, 2018 - academic.oup.com
The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …
Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration
TH Ambrosi, A Scialdone, A Graja, S Gohlke, AM Jank… - Cell stem cell, 2017 - cell.com
Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This
process is thought to impair osteogenic and hematopoietic regeneration. Here we specify …
process is thought to impair osteogenic and hematopoietic regeneration. Here we specify …
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow
The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …
Anatomical, physiological, and functional diversity of adipose tissue
Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …
Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration
Hematopoietic stem cells (HSCs) regenerate after myeloablation, a procedure that adversely
disrupts the bone marrow and drives leptin receptor-expressing cells, a key niche …
disrupts the bone marrow and drives leptin receptor-expressing cells, a key niche …
Energy metabolism of the osteoblast: implications for osteoporosis
Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …
Parathyroid hormone directs bone marrow mesenchymal cell fate
Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …
Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits
To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we
created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride …
created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride …
The bone marrow protects and optimizes immunological memory during dietary restriction
Mammals evolved in the face of fluctuating food availability. How the immune system adapts
to transient nutritional stress remains poorly understood. Here, we show that memory T cells …
to transient nutritional stress remains poorly understood. Here, we show that memory T cells …