[HTML][HTML] Animal models of Alzheimer's disease: Applications, evaluation, and perspectives

ZY Chen, Y Zhang - Zoological Research, 2022 - ncbi.nlm.nih.gov
Although great advances in elucidating the molecular basis and pathogenesis of
Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches …

Rodent models of neuroinflammation for Alzheimer's disease

A Nazem, R Sankowski, M Bacher… - Journal of …, 2015 - Springer
Alzheimer's disease remains incurable, and the failures of current disease-modifying
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …

Okadaic acid: more than a diarrheic toxin

V Valdiglesias, MV Prego-Faraldo, E Pásaro, J Méndez… - Marine Drugs, 2013 - mdpi.com
Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is
easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be …

Zebrafish as a model organism for neurodegenerative disease

K Chia, A Klingseisen, D Sieger… - Frontiers in molecular …, 2022 - frontiersin.org
The zebrafish is increasingly recognized as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …

AlzPlatform: an Alzheimer's disease domain-specific chemogenomics knowledgebase for polypharmacology and target identification research

H Liu, L Wang, M Lv, R Pei, P Li, Z Pei… - Journal of chemical …, 2014 - ACS Publications
Alzheimer's disease (AD) is one of the most complicated progressive neurodegeneration
diseases that involve many genes, proteins, and their complex interactions. No effective …

Gold nanoparticles treatment reverses brain damage in Alzheimer's disease model

N dos Santos Tramontin, S da Silva, R Arruda… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is characterized by amyloid (A) β peptide accumulation and
intracellular neurofibrillary tangles. New hypotheses have suggested that AD involves …

Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism

PK Kamat - Neural regeneration research, 2015 - journals.lww.com
Alzheimer's disease (AD) is a neurodegenerative disorder which is remarkably
characterized by pathological hallmarks that include neurofibrillary tangles, neuronal loss …

Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology

PK Kamat, S Rai, C Nath - Neurotoxicology, 2013 - Elsevier
Okadaic acid (OKA) is one of the main polyether toxins produced by marine microalgae
which causes diarrhetic shellfish poisoning. It is a selective and potent inhibitor of …

Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: a therapeutic intervention for treatment of sporadic Alzheimer's disease (sAD …

PK Kamat, A Kalani, S Rai, SK Tota, A Kumar… - Molecular …, 2016 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that is remarkably characterized
by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal …

Toxin-induced experimental models of learning and memory impairment

SV More, H Kumar, DY Cho, YS Yun… - International journal of …, 2016 - mdpi.com
Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …