Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …

When a protein's function cannot be experimentally determined, it can often be inferred from
sequence similarity. Should this process fail, analysis of the protein structure can provide …

Background Today, recognition and classification of sequence motifs and protein folds is a
mature field, thanks to the availability of numerous comprehensive and easy to use software …

Single nucleotide variants (SNVs) are, together with copy number variation, the primary
source of variation in the human genome and are associated with phenotypic variation such …

Enzymes catalyse numerous reactions in nature, often causing spectacular accelerations in
the catalysis rate. One aspect of understanding how enzymes achieve these feats is to …

Here, a scalable, accurate, reliable, and robust protein functional site comparison algorithm
is presented. The key components of the algorithm consist of a reduced representation of the …

Enzyme evolution is often constrained by aspects of catalysis. Sets of homologous proteins
that catalyze different overall reactions but share an aspect of catalysis, such as a common …

Metals are present in more than one-third of all proteins as they occur in nature, and are
usually important in biological function or maintenance of the structure. Some are present as …

An incomplete understanding of protein sequence/structure/function relationships causes
many difficulties for prediction methods. The highly complex nature of these relationships is …

The representation of protein structures as small‐world networks facilitates the search for
topological determinants, which may relate to functionally important residues. Here, we …