Permeability of the endothelial barrier: identifying and reconciling controversies
Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …
Targeting FAK in anticancer combination therapies
JC Dawson, A Serrels, DG Stupack… - Nature Reviews …, 2021 - nature.com
Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …
Pre-metastatic niches: organ-specific homes for metastases
It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …
tumour cells, but are instead selectively and actively modified by the primary tumour before …
FAK in cancer: from mechanisms to therapeutic strategies
HH Chuang, YY Zhen, YC Tsai, CH Chuang… - International journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …
activated in many cancer types. FAK regulates diverse cellular processes, including growth …
Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability
YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
FAK in cancer: mechanistic findings and clinical applications
FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …
Passing the vascular barrier: endothelial signaling processes controlling extravasation
N Wettschureck, B Strilic… - Physiological …, 2019 - journals.physiology.org
A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
[HTML][HTML] Tissue invasion and metastasis: Molecular, biological and clinical perspectives
WG Jiang, AJ Sanders, M Katoh, H Ungefroren… - Seminars in cancer …, 2015 - Elsevier
Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …
MDSCs: key criminals of tumor pre-metastatic niche formation
Y Wang, Y Ding, N Guo, S Wang - Frontiers in immunology, 2019 - frontiersin.org
The emergence of disseminated metastases remains the primary cause of mortality in
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …
Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?
I Belhabib, S Zaghdoudi, C Lac, C Bousquet, C Jean - Cancers, 2021 - mdpi.com
Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …