Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Regulation of transcription factors by neuronal activity
AE West, EC Griffith, ME Greenberg - Nature Reviews Neuroscience, 2002 - nature.com
Synaptic activity regulates the expression of a set of neuronal gene products that are
important for neuronal survival and differentiation, synaptogenesis and, ultimately, complex …
important for neuronal survival and differentiation, synaptogenesis and, ultimately, complex …
The signaling and pharmacology of the dopamine D1 receptor
J Jones-Tabah, H Mohammad, EG Paulus… - Frontiers in Cellular …, 2022 - frontiersin.org
The dopamine D1 receptor (D1R) is a Gαs/olf-coupled GPCR that is expressed in the
midbrain and forebrain, regulating motor behavior, reward, motivational states, and cognitive …
midbrain and forebrain, regulating motor behavior, reward, motivational states, and cognitive …
The dynorphin/κ-opioid receptor system and its role in psychiatric disorders
HA Tejeda, TS Shippenberg, R Henriksson - Cellular and Molecular Life …, 2012 - Springer
The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and
pathophysiology of several psychiatric disorders. In the present review, we present evidence …
pathophysiology of several psychiatric disorders. In the present review, we present evidence …
The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors
I Landa, S Ruiz-Llorente, C Montero-Conde… - PLoS …, 2009 - journals.plos.org
In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a
candidate gene approach. We studied tag-and putative functional SNPs in genes involved in …
candidate gene approach. We studied tag-and putative functional SNPs in genes involved in …
Calcium signaling in synapse-to-nucleus communication
AM Hagenston, H Bading - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Changes in the intracellular concentration of calcium ions in neurons are involved in neurite
growth, development, and remodeling, regulation of neuronal excitability, increases and …
growth, development, and remodeling, regulation of neuronal excitability, increases and …
Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models
B Mellstrom, M Savignac… - Physiological …, 2008 - journals.physiology.org
Calcium is the most universal signal used by living organisms to convey information to many
different cellular processes. In this review we present well-known and recently identified …
different cellular processes. In this review we present well-known and recently identified …
The role of calcium‐binding proteins in the control of transcription: structure to function
Transcriptional regulation is coupled with numerous intracellular signaling processes often
mediated by second messengers. Now, growing evidence points to the importance of Ca2+ …
mediated by second messengers. Now, growing evidence points to the importance of Ca2+ …
Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+-sensor proteins
KH Braunewell, AJK Szanto - Cell and tissue research, 2009 - Springer
The visinin-like protein (VSNL) subfamily, including VILIP-1 (the founder protein), VILIP-2,
VILIP-3, hippocalcin, and neurocalcin δ, constitute a highly homologous subfamily of …
VILIP-3, hippocalcin, and neurocalcin δ, constitute a highly homologous subfamily of …
Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3
M Osawa, KI Tong, C Lilliehook, W Wasco… - Journal of Biological …, 2001 - ASBMB
Calsenilin/DREAM/KChIP3, a member of the recoverin branch of the EF-hand superfamily,
interacts with presenilins, serves as a calcium-regulated transcriptional repressor, and …
interacts with presenilins, serves as a calcium-regulated transcriptional repressor, and …