[HTML][HTML] CRISPR/Cas9-engineered mesenchymal stromal/stem cells and their extracellular vesicles: A new approach to overcoming cell therapy limitations

A Hazrati, K Malekpour, S Soudi… - Biomedicine & …, 2022 - Elsevier
Cell therapy is one of the newest therapeutic approaches for treating tissue destruction
diseases and replacing damaged parts in defective tissues. Among different cells …

[PDF][PDF] Immune consequences of endothelial cells' activation and dysfunction during sepsis

S Pons, M Arnaud, M Loiselle, E Arrii, E Azoulay… - Critical care clinics, 2020 - Elsevier
The endothelium has a fundamental role in many essential physiologic functions. Its
heterogeneity in morphology and function explains that its roles can vary from one organ to …

Endothelial progenitor cells-derived exosomal microRNA-21-5p alleviates sepsis-induced acute kidney injury by inhibiting RUNX1 expression

Y Zhang, H Huang, W Liu, S Liu, XY Wang… - Cell death & …, 2021 - nature.com
Abstract The role of microRNA-21-5p (miR-21-5p) in sepsis-induced acute kidney injury
(AKI) has been seldom discussed. Therefore, the objective of this present study was to …

Endothelial progenitor cells in the host defense response

X Shi, KA Seidle, KJ Simms, F Dong, WM Chilian… - Pharmacology & …, 2023 - Elsevier
Extensive injury of endothelial cells in blood vasculature, especially in the microcirculatory
system, frequently occurs in hosts suffering from sepsis and the accompanied systemic …

Contemporary trends in global mortality of sepsis among young infants less than 90 days: a systematic review and meta-analysis

MY Gan, WL Lee, BJ Yap, STT Seethor… - Frontiers in …, 2022 - frontiersin.org
Objective Current knowledge on the global burden of infant sepsis is limited to population-
level data. We aimed to summarize global case fatality rates (CFRs) of young infants with …

Blood vessels and peripheral nerves as key players in cancer progression and therapy resistance

N Roda, G Blandano, PG Pelicci - Cancers, 2021 - mdpi.com
Simple Summary The interactions between cancer cells and the surrounding blood vessels
and peripheral nerves are critical in all the phases of tumor development. Accordingly …

Endothelial progenitor cells: new targets for therapeutics for inflammatory conditions with high cardiovascular risk

N Edwards, AWW Langford-Smith, FL Wilkinson… - Frontiers in …, 2018 - frontiersin.org
Over the past decade, we have witnessed an exponential growth of interest into the role of
endothelial progenitor cells (EPCs) in cardiovascular disease. While the major thinking …

The Long Telling Story of “Endothelial Progenitor Cells”: Where Are We at Now?

MC Vinci, E Carulli, E Rurali, R Rinaldi, G Damiano… - Cells, 2022 - mdpi.com
Endothelial progenitor cells (EPCs): The name embodies years of research and clinical
expectations, but where are we now? Do these cells really represent the El Dorado of …

Increased circulation mobilization of endothelial progenitor cells in preterm infants with retinopathy of prematurity

H Babaei, M Alibabrdel, S Asadian… - Journal of cellular …, 2018 - Wiley Online Library
Retinopathy of prematurity (ROP) is a result of increased pathological neoangiogenesis of
the retina in preterm infants. Cells responsible for the pathogenesis of ROP are unclear, but …

Mobilization of endothelial progenitor cells in sepsis

R Sun, J Huang, B Sun - Inflammation Research, 2020 - Springer
Purpose Sepsis, an intractable clinical syndrome, is often accompanied by severe vascular
endothelial injury and barrier dysfunction. Previous evidence has shown that the …