Determinants of enhancer and promoter activities of regulatory elements
R Andersson, A Sandelin - Nature Reviews Genetics, 2020 - nature.com
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
Enhancer RNAs are an important regulatory layer of the epigenome
V Sartorelli, SM Lauberth - Nature structural & molecular biology, 2020 - nature.com
Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development
and disease through their regulation of transcription, RNA processing and translation …
and disease through their regulation of transcription, RNA processing and translation …
Long noncoding RNAs: molecular modalities to organismal functions
We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …
functions across most forms of life. The maintenance of chromosome length requires an …
Eukaryotic core promoters and the functional basis of transcription initiation
Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …
transcription start sites of protein-coding and non-coding genes that support the assembly of …
Molecular and evolutionary processes generating variation in gene expression
Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …
variation arises from mutations that alter the form or function of molecular gene regulatory …
Structural insights into preinitiation complex assembly on core promoters
INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
Census and evaluation of p53 target genes
M Fischer - Oncogene, 2017 - nature.com
The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …
gene alters its response pathway, and is central to the development of many cancers. The …
Intragenic DNA methylation prevents spurious transcription initiation
In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …
promoter suppresses gene expression, but the functional role of gene-body DNA …
MicroRNAs and complex diseases: from experimental results to computational models
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …
viruses and animals. As one of the most important components in the cell, miRNAs play a …
Sequence determinants of human gene regulatory elements
DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the …
determinants that control gene expression is unknown. Here, we measured the …