[HTML][HTML] The intestinal barrier and current techniques for the assessment of gut permeability
I Schoultz, ÅV Keita - Cells, 2020 - mdpi.com
The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …
[HTML][HTML] Dendrimers in the context of nanomedicine
AP Dias, S da Silva Santos, JV da Silva… - International journal of …, 2020 - Elsevier
Dendrimers are globular structures, presenting an initiator core, repetitive layers starting
radially from the core and terminal groups on the surface, resembling tree architecture …
radially from the core and terminal groups on the surface, resembling tree architecture …
Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects
S Barua, S Mitragotri - Nano today, 2014 - Elsevier
Nanoparticles (NPs) have emerged as an effective modality for the treatment of various
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …
Endocytosis of nanomedicines
Novel nanomaterials are being developed to improve diagnosis and therapy of diseases
through effective delivery of drugs, biopharmaceutical molecules and imaging agents to …
through effective delivery of drugs, biopharmaceutical molecules and imaging agents to …
Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications
AR Menjoge, RM Kannan, DA Tomalia - Drug discovery today, 2010 - Elsevier
Dendrimers are members of a versatile, fourth new class of polymer architecture (ie dendritic
polymers after traditional linear, crosslinked and branched types)[1]. Typically, dendrimers …
polymers after traditional linear, crosslinked and branched types)[1]. Typically, dendrimers …
Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment
The therapeutic potential of miRNA (miR) in cancer is limited by the lack of efficient delivery
vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure …
vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure …
[HTML][HTML] Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines
Nanotechnology is expected to play a vital role in the rapidly developing field of
nanomedicine, creating innovative solutions and therapies for currently untreatable …
nanomedicine, creating innovative solutions and therapies for currently untreatable …
Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery
S Sadekar, H Ghandehari - Advanced drug delivery reviews, 2012 - Elsevier
This article summarizes efforts to evaluate poly (amido amine)(PAMAM) dendrimers as
carriers for oral drug delivery. Specifically, the effect of PAMAM generation, surface charge …
carriers for oral drug delivery. Specifically, the effect of PAMAM generation, surface charge …
Co-delivery of cisplatin and doxorubicin by covalently conjugating with polyamidoamine dendrimer for enhanced synergistic cancer therapy
Because of the synergistic effects of drugs and minimal drug dose for cancer therapy,
combination chemotherapy is frequently used in the clinic. In this study, hyaluronic acid …
combination chemotherapy is frequently used in the clinic. In this study, hyaluronic acid …
Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery
Oral route is the most common route for the delivery of drugs because it is simple to
implement and improves patient compliance and quality of life. However, oral absorption is …
implement and improves patient compliance and quality of life. However, oral absorption is …