Circadian rhythms in neurodegenerative disorders

M Nassan, A Videnovic - Nature Reviews Neurology, 2022 - nature.com
Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

[HTML][HTML] Is melatonin the cornucopia of the 21st century?

N Ferlazzo, G Andolina, A Cannata, MG Costanzo… - Antioxidants, 2020 - mdpi.com
Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Glymphatic system dysfunction and sleep disturbance may contribute to the pathogenesis and progression of Parkinson's disease

A Massey, MK Boag, A Magnier, DPCF Bispo… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

Melatonin in food allergy: Mechanism and potential therapy

H Wang, Y Yan, I Hung, C Liu, J Yin… - Journal of Pineal …, 2023 - Wiley Online Library
Food allergy affects more than 500 million people in the world, and its prevalence is
increasing at an alarming rate causing serious public health concerns; however, prevention …

Roles of clock genes in the pathogenesis of Parkinson's disease

AD Shkodina, SC Tan, MM Hasan… - Ageing Research …, 2022 - Elsevier
Parkinson's disease (PD) is a common motor disorder that has become increasingly
prevalent in the ageing population. Recent works have suggested that circadian rhythms …

Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: mechanisms and interventions

R Fan, X Peng, L Xie, K Dong, D Ma, W Xu, X Shi… - Aging cell, 2022 - Wiley Online Library
With the aging world population, the prevalence of aging‐related disorders is on the rise.
Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's …

Neuroprotective effect of melatonin on Sleep disorders Associated with Parkinson's Disease

X Hu, J Li, X Wang, H Liu, T Wang, Z Lin, N Xiong - Antioxidants, 2023 - mdpi.com
Parkinson's disease (PD) is a complex, multisystem disorder with both neurologic and
systemic manifestations, which is usually associated with non-motor symptoms, including …

Effect of melatonin administration on mitochondrial activity and oxidative stress markers in patients with Parkinson's disease

A Jiménez-Delgado, GG Ortiz… - Oxidative Medicine …, 2021 - Wiley Online Library
Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease
(PD) pathogenesis. Melatonin is a pleiotropic molecule with antioxidant and neuroprotective …

Melatonin treatment for sleep disorders in Parkinson's disease: a meta-analysis and systematic review

H Ma, J Yan, W Sun, M Jiang, Y Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Objective The efficacy of melatonin on sleep disorders in Parkinson's disease (PD) is still
unclear. The purpose of this study was to investigate the efficacy of melatonin on sleep …

Management of sleep disturbances in Parkinson's disease

L Schütz, F Sixel-Döring… - Journal of Parkinson's …, 2022 - content.iospress.com
Parkinson's disease (PD) is defined by its motor symptoms rigidity, tremor, and akinesia.
However, non-motor symptoms, particularly autonomic disorders and sleep disturbances …