Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

Prostate specific antigen (PSA) or human kallikrein 3 (hK3) has long been an effective
biomarker for prostate cancer. Now, other members of the tissue kallikrein (KLK) gene family …

Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that
regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely …

Tissue kallikrein, a serine proteinase, produces the potent vasodilator kinin peptide from
kininogen substrate. The levels of tissue kallikrein are reduced in humans and animal …

Tissue kallikrein (KLK1) processes low-molecular weight kininogen to produce vasoactive
kinins, which exert biological functions via kinin receptor signaling. Using various delivery …

Tissue kallikrein (hK1) cleaves low-molecular-weight kininogen to produce kinin peptide,
which binds to kinin receptors and triggers a wide spectrum of biological effects. Tissue …

The kallikrein family of serine proteases has been investigated in many inflammatory
disorders as molecular mapping, gene characterisation and cloning of kinin receptor genes …

Rheumatoid arthritis is a chronic multi-system disease of unknown aetiology. The current
hypothesis is that an unknown antigen triggers an autoimmune response in a genetically …

We have studied the immunohistochemical expression (IE) of eight non-tissue-specific
human kallikreins (hKs)(hK5, 6, 7, 10, 11, 12, 13, and 14) in different normal tissues. The IE …

The progression of renal disease displays several characteristics, including proteinuria,
apoptosis, inflammation, and fibrosis. In this study, we investigated the effect of long-term …