[HTML][HTML] The role of inflammation in diabetes: current concepts and future perspectives

S Tsalamandris, AS Antonopoulos… - European cardiology …, 2019 - ncbi.nlm.nih.gov
Diabetes is a complex metabolic disorder affecting the glucose status of the human body.
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …

Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches

D Tousoulis, N Papageorgiou, E Androulakis… - Journal of the American …, 2013 - jacc.org
It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase
activity as well as enhances the production of reactive oxygen species, thus resulting in …

[HTML][HTML] Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function

Y Ding, Y Zhou, P Ling, X Feng, S Luo, X Zheng… - Theranostics, 2021 - ncbi.nlm.nih.gov
As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …

The vascular neural network—a new paradigm in stroke pathophysiology

JH Zhang, J Badaut, J Tang, A Obenaus… - Nature Reviews …, 2012 - nature.com
The concept of the neurovascular unit as the key brain component affected by stroke is
controversial, because current definitions of this entity neglect mechanisms that control …

The main determinants of diabetes mellitus vascular complications: endothelial dysfunction and platelet hyperaggregation

A Carrizzo, C Izzo, M Oliveti, A Alfano… - International journal of …, 2018 - mdpi.com
Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy.
In some countries of northern Europe or in North America, it can even affect 6–8% of the …

Neutrophil–lymphocyte ratio is a reliable predictive marker for early‐stage diabetic nephropathy

W Huang, J Huang, Q Liu, F Lin, Z He… - Clinical …, 2015 - Wiley Online Library
Introduction Diabetic nephropathy (DN) is a common complication in diabetics. Recent
evidence suggests that neutrophil–lymphocyte ratio (NLR) affects the development and …

Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study

AM Hutchins, BD Brown, SC Cunnane, SG Domitrovich… - Nutrition research, 2013 - Elsevier
The study hypothesis was that fasting glucose, insulin, fructosamine, C-reactive protein, and
interleukin-6 decrease and adiponectin increases with daily flaxseed consumption in …

The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus

T Xu, Z Weng, C Pei, S Yu, Y Chen, W Guo, X Wang… - Medicine, 2017 - journals.lww.com
The relationship between neutrophil-to-lymphocyte ratio and... : Medicine The relationship
between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes …

Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation

Y Dai, JL Mehta, M Chen - Cardiovascular drugs and therapy, 2013 - Springer
Purpose The increase in endothelin-1 (ET-1) and the decrease in endothelial nitric oxide
synthase (eNOS) both induce vasoconstriction and lead to molecular changes associated …

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

ND Jayaraj, BJ Bhattacharyya… - The Journal of …, 2018 - Am Soc Clin Investig
Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25%
of patients. PDN is characterized by neuropathic pain and small-fiber degeneration …