Microneedle-mediated transdermal delivery of biopharmaceuticals

HX Nguyen, CN Nguyen - Pharmaceutics, 2023 - mdpi.com
Transdermal delivery provides numerous benefits over conventional routes of
administration. However, this strategy is generally limited to a few molecules with specific …

Progress in microneedle-mediated protein delivery

R Jamaledin, C Di Natale, V Onesto… - Journal of clinical …, 2020 - mdpi.com
The growing demand for patient-compliance therapies in recent years has led to the
development of transdermal drug delivery, which possesses several advantages compared …

Electroanalytical sensor based on gold-nanoparticle-decorated paper for sensitive detection of copper ions in sweat and serum

N Bagheri, V Mazzaracchio, S Cinti, N Colozza… - Analytical …, 2021 - ACS Publications
The growth of (bio) sensors in analytical chemistry is mainly attributable to the development
of affordable, effective, portable, and user-friendly analytical tools. In the field of sensors …

A comprehensive analysis of the intrinsic visible fluorescence emitted by peptide/protein amyloid-like assemblies

N Balasco, C Diaferia, E Rosa, A Monti, M Ruvo… - International journal of …, 2023 - mdpi.com
Amyloid aggregation is a widespread process that involves proteins and peptides with
different molecular complexity and amino acid composition. The structural motif (cross-β) …

A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action

S La Manna, C Di Natale, V Panzetta, M Leone… - Inorganic …, 2023 - ACS Publications
The physical and chemical properties of paddlewheel diruthenium compounds are highly
dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare …

Glucosyl platinum (II) complexes inhibit aggregation of the C-terminal region of the Aβ peptide

S La Manna, M Leone, I Iacobucci… - Inorganic …, 2022 - ACS Publications
Neurodegenerative diseases are often caused by uncontrolled amyloid aggregation. Hence,
many drug discovery processes are oriented to evaluate new compounds that are able to …

Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo [c] phenanthridine and berberine-based compounds on β-amyloid …

D Marasco, C Vicidomini, P Krupa, F Cioffi… - Chemico-biological …, 2021 - Elsevier
Herein we present a comparative study of the effects of isoquinoline alkaloids belonging to
benzo [c] phenanthridine and berberine families on β-amyloid aggregation. Results …

A comparative study of the effects of platinum (II) complexes on β-amyloid aggregation: Potential neurodrug applications

SL Manna, D Florio, I Iacobucci, F Napolitano… - International journal of …, 2021 - mdpi.com
Herein the effects of three platinum complexes, namely (SP-4-2)-(2, 2′-bipyridine)
dichloridoplatinum (II), Pt-bpy,(SP-4-2)-dichlorido (1, 10-phenanthroline) platinum (II), Pt …

PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach

R Jamaledin, R Sartorius, C Di Natale, V Onesto… - Journal of Nanostructure …, 2024 - Springer
Bacteriophages have attracted great attention in the bioengineering field in diverse research
areas from tissue engineering to therapeutic and clinical applications. Recombinant …

Metal–peptide complexes as promising antibiotics to fight emerging drug resistance: New perspectives in tuberculosis

C Di Natale, I De Benedictis, A De Benedictis… - Antibiotics, 2020 - mdpi.com
In metal-peptide interactions, cations form stable complexes through bonds with
coordinating groups as side chains of amino acids. These compounds, among other things …