Preclinical and clinical neurophysiological and neurorehabilitation research has generated
rather surprising levels of recovery of volitional sensory-motor function in persons with …

Central pattern generators (CPGs) are generally defined as networks of neurons capable of
enabling the production of central commands, specifically controlling stereotyped, rhythmic …

Neuronal networks generating hindlimb locomotion are located in the spinal cord. The
mechanisms underlying spinal rhythmogenesis are unknown but network activity and …

During development, all animals undergo major adaptations to accommodate behavioral
flexibility and diversity. How these adaptations are reflected in the changes in the motor …

During the last 50 years, the serotonergic (5-HT) system was reported to exert a complex
modulation of locomotor activity. Here, we focus on two key factors that likely contribute to …

Key points Experiments on neonatal rodent spinal cord showed that serotonin (5‐HT), acting
via 5‐HT7 receptors, is required for initiation of locomotion and for controlling the action of …

Mapping the expression of transcription factors in the mouse spinal cord has identified ten
progenitor domains, four of which are cardinal classes of molecularly defined, ventrally …

Locomotion is mediated by spinal circuits that generate movements with a precise
coordination and vigor. The assembly of these circuits is defined early during development; …

Neural circuitry generating locomotor rhythm and pattern is located in the spinal cord. Most
spinal cord injuries (SCIs) occur above the level of spinal locomotor neurons; therefore …

The adult decerebrate mouse model (a mouse with the cerebrum removed) enables the
study of sensory-motor integration and motor output from the spinal cord for several hours …