Internal tandem duplication mutations in fms-like tyrosine kinase 3 (FLT3-ITD) are recurrent
in acute myeloid leukemia (AML) and increase the risk of relapse. Clinical responses to …

Leukaemia stem cells (LSCs) are the critical seed for the growth of haematological
malignancies, driving the clonal expansion that enables disease initiation, relapse and often …

There is an ever-growing choice of single-cell and spatial'omics platforms for industry and
academia. The scTrends Consortium provides a brief historical overview of the established …

Disordered chromatin organization has emerged as a new aspect of pathogenesis of
myelodysplastic syndromes (MDS). Characterized by lineage dysplasia and high …

Hematopoiesis is a continuous process of blood cell production driven by hematopoietic
stem and progenitor cells (HSPCs) in the bone marrow. Proliferation and differentiation of …

A significant variation in chromatin accessibility is an epigenetic feature of leukemia. The
cause of this variation in leukemia, however, remains elusive. Here, we identify SMARCA5 …

Background Genetic perturbation screens with single cell readouts have enabled rich
phenotyping of gene function and regulatory networks. These approaches have been …

A healthy hematopoietic system relies on proper cell fate decisions, which ensure balanced
self‐renewal and differentiation programs. In this context, the dynamic regulation of the …

Hematopoietic stem cells (HSCs) are a rare but potent cell type that support life-long
hematopoiesis and will stably regenerate the entire blood and immune system following …

Macrophages elicit immune responses to pathogens through induction of inflammatory
genes. Here, we examined the role of three variants of the SWI/SNF nucleosome remodeling …